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目的:观察阿普唑仑和氟西汀治疗肠易激综合征(IBS)的疗效。方法:在常规疗法基础上,分别联用阿普唑仑和氟西汀治疗顽固性肠易激综合征(IBS) 12 6例8周,并与单用常规疗法对照,评测其治疗前后肠易激综合征问卷、生活质量问卷和综合医院焦虑抑郁量表积分变化。结果:治疗后3组患者IBS症状(F=96 .0 5 5 )、肠外症状(F=2 7.4 76 )、生活质量(F=2 6 .813)、焦虑(F=10 .813)和抑郁(F=34.133)状况比较,差异有统计学意义(P<0 .0 0 1)。阿普唑仑组和氟西汀组之间IBS症状(t=0 .349,P=0 .72 8)、肠外症状(t=0 .5 0 7,P=0 .6 14 )和生活质量(t=0 .16 2 ,P=0 .872 )积分差异无统计学意义。阿普唑仑控制焦虑症状优于氟西汀,但差异未达显著性(t=1.6 6 0 ,P=0 .10 1) ;控制抑郁症状方面阿普唑仑则不及氟西汀(t=6 .5 88,P<0 .0 0 1) ,但仍优于常规疗法(t=2 .5 2 8,P=0 .0 14 )。结论:阿普唑仑和氟西汀能够改善IBS的腹部症状和提高生活质量,疗效与精神症状改善不平行。
Objective: To observe the efficacy of alprazolam and fluoxetine in treating irritable bowel syndrome (IBS). Methods: On the basis of conventional therapy, alprazolam and fluoxetine were respectively used to treat 12 6 patients with refractory irritable bowel syndrome (IBS) for 8 weeks. Compared with conventional therapy alone, Irritable bowel syndrome questionnaire, quality of life questionnaire and general hospital anxiety and depression scale changes. Results: The IBS symptoms (F = 96.505), extraintestinal symptoms (F = 2 7.476), quality of life (F = 26.813), anxiety (F = 10.813) and Depression (F = 34.133), the difference was statistically significant (P <0. 001). IBS symptoms (t = 0.349, P = 0.72 8), extraintestinal symptoms (t = 0.507, P = 0.604) and life among alprazolam and fluoxetine groups There was no significant difference in the scores of quality (t = 0.16 2, P = 0.882). Alprazolam was superior to fluoxetine in controlling anxiety, but the difference was not significant (t = 1.660, P = 0.101). Alprazolam was less effective than fluoxetine in controlling depression (t = 6 .588, P <0.001), but still better than the conventional therapy (t = 2. 528, P = 0.014). Conclusion: Alprazolam and fluoxetine can improve the abdominal symptoms and improve the quality of life in patients with IBS. The curative effect is not in parallel with the improvement of psychiatric symptoms.