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目的：探讨氧化苦参碱（ＯＭ）对大鼠溃疡性结肠炎（ＵＣ）的保护作用。方法：用葡聚糖硫酸钠（ＤＳＳ）诱导大鼠结肠 炎，对比ＯＭ组、ＤＳＳ对照组和正常对照组的疾病活动度（ＤＡＩ）及病理学评分。结果：两项指标在３组间均存在显著 差异（Ｐ＜０．０５）。结论：ＯＭ能够减轻ＤＳＳ诱导的结肠炎症状和肠粘膜损害。
Objective: To investigate the protective effect of oxymatrine (OM) on ulcerative colitis (UC) in rats. Methods: Colitis induced by dextran sodium sulfate (DSS) was used to compare the disease activity (DAI) and pathological score of OM group, DSS control group and normal control group. Results: There were significant differences between the two indexes in the three groups (P <0.05). Conclusion: OM can alleviate the symptoms of colitis and intestinal mucosal damage induced by DSS.