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本文中,Pool JL对合并高血压和良性前列腺增生(BPH)的治疗进行了综述。高血压和BPH由交感神经系统而联系起来,因其在这两种病的发病中均起作用。α1肾上腺素能受体介导血管和前列腺平滑肌张力增加。一些研究已经证实多沙唑嗪通过对α1肾上腺素能受体不同亚型的平衡作用,降低血压并改善其它一些冠心病的影响因子,如脂代谢,胰岛素敏感性,左心室肥大,血小板聚集和纤维蛋白溶解等。显示多沙唑嗪提高前列腺增生患者尿流率和改善排尿症状的资
Here, Pool JL reviews the treatment of hypertension and benign prostatic hyperplasia (BPH). Hypertension and BPH are linked by the sympathetic nervous system, as they both play a role in the pathogenesis of both diseases. Alpha 1 adrenergic receptors mediate increased tension in smooth muscle of blood vessels and prostatic. Some studies have confirmed that doxazosin can reduce the blood pressure and improve some other coronary heart disease factors by balancing the different subtypes of α1 adrenergic receptor such as lipid metabolism, insulin sensitivity, left ventricular hypertrophy, platelet aggregation and Fibrinolysis and so on. Doxazosin showed increased urinary flow in patients with benign prostatic hyperplasia and improve urinary symptoms of the capital