在AZ81镁合金表面制备了抗腐蚀和药物释放复合涂层,并对其耐蚀性、药物释放性能及生物相容性进行研究。DSC和红外光谱数据表明,紫杉醇均匀分散在PLGA体系中。药物释放数据表明30 d后,药物释放率在80%左右。SEM、电化学阻抗、极化及镁离子释放数据表明,PLLA涂层通过有效填充微弧氧化膜表面的微孔与裂缝提高了镁合金的耐腐蚀性。血液和细胞实验表明涂层镁合金血液相容性良好,无细胞毒性。 Corrosion resistance and drug release composite coatings were prepared on the surface of AZ81 magnesium alloy and its corrosion resistance, drug release properties and biocompatibility were studied. DSC and FTIR data showed that paclitaxel was uniformly dispersed in the PLGA system. Drug release data show that after 30 days, the drug release rate is about 80%. SEM, electrochemical impedance, polarization and magnesium ion release data show that the PLLA coating through the micro-arc oxidation coating to effectively increase the surface micro-pores and cracks improve the corrosion resistance of magnesium alloys. Blood and cell experiments show that the coated magnesium alloy has good blood compatibility and no cytotoxicity.