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目的:研究早期肠内营养(EEN)对重度颅脑损伤病人治疗效果的影响。方法:选取重度颅脑损伤病人30例,随机分为早期(伤后24 h内)EN组;延迟(伤后24~48 h内)EN组;早期(伤后24 h内)肠外营养(PN)组。比较三组病人伤后第1和第7天以及3个月时的生存率、格拉斯哥昏迷(GCS)评分恢复情况、肺部感染率和血清球蛋白水平。结果:在伤后第1和第7天时,各组病人的生存率、GCS评分恢复情况、肺部感染率均无统计学差异(P>0.05)。而在伤后3个月时,EEN组上述三个指标与其他两组相比均有统计学差异(P<0.05);血清球蛋白水平在伤后第7天时EEN组与其他两组相比均有统计学差异(P<0.05)。结论:对于重度颅脑损伤病人EEN可提高其生存率,降低肺部感染发生率,改善GCS评分,并可提高急性期内病人的免疫功能。
Objective: To study the effect of early enteral nutrition (EEN) on the treatment of patients with severe craniocerebral injury. Methods: Thirty patients with severe craniocerebral injury were enrolled in this study. They were randomly divided into EN group (24 hours after injury), EN group (EN group within 24-48 hours after injury), EN group (within 24 hours after injury) PN) group. Survival rates, recovery of Glasgow coma (GCS) scores, lung infection rates and serum globulin levels were compared between the first and seventh days and at 3 months after injury among the three groups. Results: On the 1st and the 7th day after injury, there was no significant difference in survival rate, recovery of GCS score and lung infection rate in all groups (P> 0.05). At 3 months after injury, the above three indexes in EEN group were significantly different from those in the other two groups (P <0.05). Compared with the other two groups, the level of serum globulin at the 7th day after injury There was statistical difference (P <0.05). Conclusion: EEN can improve the survival rate, reduce the incidence of pulmonary infection, improve the GCS score and improve the immune function in patients with severe craniocerebral injury.