Objective:Prostate cancer is a form of cancer that develops in the prostate,a gland in the male reproductive system.Prostate cancer tends to develop in men over the age of fifty;it is one of the most prevalent types of cancer in men.This article introduced a new method of prostate cancer treatment with the combination of three dimensional conformal radiation therapy (3D-CRT) and high-intensity focused ultrasound (HIFU),its efficacy was evaluated.Methods:From January 2004 to December 2009,95 patients were diagnosed with prostate cancer,among them,48 patients were received combined therapy with total irradiation of TD 60 Gy/30 Fx and 5 fractions of HIFU treatment,while 47 patients were received with pure 3D-CRT with total irradiation of TD (66-72) Gy/(33-36) Fx.Various indicators were evaluated,such as the local control rate and distant metastasis rate,the changes in blood PSA and fPSA,changes in T-lymphocyte subsets and NK cells,as well as acute adverse reaction of normal tissue.Results:The local response rate difference between the two groups had statistical significance (P < 0.05);the changes in blood PSA and fPSA were significant (P < 0.05);CD3+,CD4+,CD8+,CD4+/CD8+ and NK cells of the combined group increased obviously (P < 0.01),while the latter group had no increase (P > 0.05);the combined group had lower blood cells reduction and II-level acute adverse reaction of rectum,bladder and caput humeri than the pure group,but the II-level acute adverse reaction of urogenital canal in the combined group was higher (P < 0.05).Conclusion:The combined therapy with 3D-CRT and HIFU is a good way for the treatment of aged-related prostate cancer.It can ease the symptoms,control the disease and lengthen the survival time. Objective: Prostate cancer is a form of cancer that develops in the prostate, a gland in the male reproductive system. Prostate cancer tends to develop in men over the age of fifty; it is one of the most prevalent types of cancer in men. article introduced a new method of prostate cancer treatment with the combination of three dimensional conformal radiation therapy (3D-CRT) and high-intensity focused ultrasound (HIFU), its efficacy was evaluated. Methods: From January 2004 to December 2009,95 patients were diagnosed with prostate cancer, among them 48 patients were received combined therapy with total irradiation of TD 60 Gy / 30 Fx and 5 fractions of HIFU treatment while 47 patients were received with pure 3D-CRT with total irradiation of TD (66-72 ) Gy / (33-36) Fx.Various indicators were evaluated, such as the local control rate and distant metastasis rate, the changes in blood PSA and fPSA, changes in T-lymphocyte subsets and NK cells, as well as acute adverse reaction of normal tissue.Results : The local response rate difference between the two groups had statistical significance (P <0.05); the changes in blood PSA and fPSA were significant (P <0.05); CD3 +, CD4 +, CD8 +, CD4 + / CD8 + and NK cells of the combined group while the latter group had no increase (P> 0.05); the combined group had lower blood cells reduction and II-level acute adverse reaction of rectum, bladder and caput humeri than the pure group, but the II-level acute adverse reaction of urogenital canal in the combined group was higher (P <0.05) .Conclusion: The combined therapy with 3D-CRT and HIFU is a good way for the treatment of aged-related prostate cancer. At can ease the symptoms, control the disease and lengthen the survival time.