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目的应用选择性肠道钙离子拮抗剂(匹维溴胺)治疗肠易激综合征(Irritable Bowel Syndmme,IBS),观察临床疗效以及其对回盲部肥大细胞的影响,探讨其治疗 IBS 的可能机制。方法符合人选标准的 IBS 患者80例,应用肠道钙离子拮抗剂治疗前后观察疗效以及检测回盲部脱颗粒肥大细胞的数目变化。结果应用选择性肠道钙离子拮抗剂治疗前后回盲部脱颗粒肥大细胞数目有变化。结论应用选择性肠道钙离子拮抗剂治疗腹泻型 IBS 有效,可能抑制了肥大细胞的活化,机理有待于进一步探讨。
Objective To investigate the clinical effect and its effect on mast cells of the ileocecal part in the treatment of irritable bowel syndrome (IBS) with selective intestinal calcium antagonist mechanism. Methods Eighty patients with IBS who met the standard of choice were enrolled in the study. The therapeutic effect was observed before and after treatment with intestinal calcium antagonist and the number of degranulation mast cells in the ileocecal region was measured. Results The number of degranulation mast cells in the ileocecal part was changed before and after treatment with selective intestinal calcium antagonist. Conclusion The selective intestinal calcium antagonist is effective in treating diarrhea-type IBS, which may inhibit the activation of mast cells. The mechanism remains to be further explored.