论文部分内容阅读
目的明确CR1在HBV慢性感染患者炎性期与静止期外周血红细胞表达变化及临床意义。方法应用流式细胞术检测HBV慢性感染不同人群外周血红细胞CR1(ECR1)的表达量;应用红细胞天然免疫黏附肿瘤细胞的测定方法检测ECR1分子黏附活性:以5个或以上红细胞黏附1个肿瘤细胞为一个结合单位,计算黏附率。结果慢性乙型肝炎静止期患者ECR1表达量及黏附活性均较炎症活动期患者高,有统计学差异(P<0.05);乙型肝炎肝硬化患者静止期明显高于活动期(P<0.05)。结论 ECR1表达量及黏附活性在HBV感染所致慢性肝病患者炎症活动期下降;ECR1与炎性活动可能有密切关系。
Objective To investigate the changes of peripheral blood red blood cells (CRs) and the clinical significance of CR1 in inflammatory and quiescent patients with chronic hepatitis B virus infection. Methods Flow cytometry was used to detect the expression of CRR (ECR1) in peripheral blood of patients with chronic HBV infection. The adhesion activity of ECR1 was detected by the method of immunoadsorption of natural erythrocytes. One tumor cell was adhered to 5 or more red blood cells For a binding unit, calculate the adhesion rate. Results The levels of ECR1 expression and adhesive activity in patients with chronic hepatitis B were significantly higher than those in patients with active inflammatory disease (P <0.05), and the quiescence of patients with hepatitis B cirrhosis was significantly higher than that of active patients (P <0.05) . Conclusions The expression of ECR1 and the activity of adhesion decrease in patients with chronic liver disease caused by HBV infection during inflammatory stage. ECR1 may be closely related to inflammatory activity.