下丘脑是调节饮食和能量平衡的中枢 ,由其辐射而成的“食欲调节网络”(ARN)是一个协同合作、相互影响的精细调节环路 ,其通过多种信息分子和受体系统调节摄食行为。本文重点综述了瘦素和增食欲素这两个主要调节因子及其调节过程 The hypothalamus is a central regulator of diet and energy balance. The radiant “appetite regulating network” (ARN) is a collaborative and interdisciplinary fine regulatory loop that regulates food intake through a variety of information molecules and receptor systems behavior. This article focuses on the two main regulators of leptin and orexin and their regulatory processes