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目的 :为了初步探讨幽门螺杆菌与肠化生的相关性。方法 :应用CLO test、组织学和分子生物学方法联合检测 6 5例胃粘膜活检标本中HP感染。结果 :表明肠化生组织中HP的检出率显著高于正常组。结论 :HP感染与患者年龄、性别无关。HP可能在从浅表性胃炎→肠化生→不典型增生→胃癌的发生过程中起一定作用
Objective: To investigate the relationship between Helicobacter pylori and intestinal metaplasia. Methods: HP infection in 65 gastric biopsy specimens was detected by CLO test, histological and molecular biological methods. Results: The detection rate of HP in intestinal metaplasia was significantly higher than that in normal group. Conclusion: HP infection has no relation with patient’s age and gender. HP may play a role in the pathogenesis of superficial gastritis → intestinal metaplasia → dysplasia → gastric cancer