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采用软骨细胞体外单层培养的方法，观察真菌毒素ＮＩＶ对幼兔关节软骨细胞超微结构的作用。结果表明ＮＩＶ对软骨细胞膜系统和细胞浆具有明显的损伤作用，特别是对培养早期的软骨细胞具致命的损伤，以后其损伤程度随毒素浓度的升高而加重。ＮＩＶ与大骨节病的关系有待进一步探讨。
Chondrocytes were cultured in vitro monolayer to observe the effect of mycotoxin NIV on the ultrastructure of rabbit articular chondrocytes. The results showed that NIV had a significant damage on the chondrocyte membrane system and cytoplasm, especially on the early culture of chondrocytes. After that, the degree of damage was aggravated with the increase of the toxin concentration. NIV and Kashin-Beck disease needs further study.