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对 15 9例应用国产左旋 18甲基炔诺酮皮埋避孕剂 (Cla型 )妇女血清中和外周血单个核细胞 (PBMC )自发分泌的细胞因子水平进行了测定 ,结果表明 ,在该药应用早期 (<1 5年 ) ,血清中和PBMC分泌的IL 2和TNF α水平明显高于正常对照组(P <0 0 1) ,PBMC分泌IL 6的水平则有所降低 ;而IFN γ未见明显变化 ,以上变化在中晚期 (1 5～ 6 0年 )基本恢复正常 ,并保持稳定。血清中IL 2、IL 6和TNF α的水平变化与PBMC自发分泌水平相关。PBMC在体外经PHA刺激后 ,分泌四种细胞因子的水平与正常对照组无显著性差别。
The levels of cytokines secreted by spontaneous secretion of 15 9 Chinese women who were treated with levonorgestrel-18 (C57) nifedipine-coated contraceptives (Cla type) were measured. The results showed that in the application of this medicine In the early stage (<15 years), the levels of IL 2 and TNFα secreted by serum and PBMC were significantly higher than those of the normal control group (P <0.01), and IL-6 secreted by PBMC decreased Significant changes in the above changes in the late (15 ~ 60) basically returned to normal, and remained stable. Changes in serum levels of IL 2, IL 6 and TNFα correlated with spontaneous secretion of PBMCs. PBMC stimulated by PHA in vitro, the secretion of four cytokines levels and the normal control group no significant difference.