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目的 探讨母血白细胞介素 6(IL -6)与早产亚临床绒毛膜羊膜炎及早产儿预后的关系。方法 用酶联免疫吸附实验测定 67例早产孕妇及 3 2例相同孕周正常孕妇血IL -6,分娩时取部分胎盘胎膜送病检 ,记录 1周内早产儿情况。结果 早产组血IL -6、WBC明显高于对照组 (P <0 0 5 ) ,组织学绒毛膜羊膜炎阳性组血清IL -6、C -反应蛋白 (CRP)均明显高于组织学绒毛膜羊膜炎阴性组 (P <0 0 1)。母血IL -6≥ 10ng/L比IL -6<10ng/L有较高的组织学绒毛膜羊膜炎和明显的新生儿发病率。结论 母血IL -6是预测早产亚临床绒毛膜羊膜炎及早产明显的新生儿发病率一项有用的指标
Objective To investigate the relationship between maternal serum interleukin-6 (IL-6) and preterm subclinical chorioamnionitis and the prognosis of premature infants. Methods Serum IL-6 was measured in 67 pregnant women with preterm labor and 32 normal pregnant women with the same gestational age by enzyme-linked immunosorbent assay (ELISA). Part of fetal placenta was taken for sick examination and the preterm infants were recorded within 1 week. Results The levels of IL - 6 and WBC in preterm labor group were significantly higher than those in control group (P <0.05). The serum levels of IL - 6 and C - reactive protein (CRP) in histological chorioamnionitis group were significantly higher than those in histological chorionic Amniotic negative group (P <0.01). Maternal IL-6≥10 ng / L had higher histologic chorioamnionitis and significant neonatal morbidity than IL-6 <10 ng / L. Conclusion Maternal serum IL-6 is a useful indicator for predicting the incidence of subclinical chorioamnionitis in preterm labor and preterm birth with significant neonatal morbidity