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目的：不适合手术治疗的中晚期食管癌，联合化疗全身用药加局部照射可提高其疗效。方法：对120例不能手术切除的中晚期食管癌患者随机分为化疗加放疗组和单纯放疗组，各为60例。两组照射方法相同DT50－70GY／5－7周。化疗使用FD方案，化疗在放疗前后各行一次。结果：1、2、3年生存率，化疗加放疗组为70．0％，53．3％，31．7％。单纯放疗组为46．7％，36.7％，20．0％。两组1、2、3年生存率对比有显著差异（P＜0．05）；结论：中位生存期，化疗加放疗组明显高于单放组。
OBJECTIVE: To treat advanced esophageal cancer that is not suitable for surgery, combined with systemic chemotherapy plus local irradiation can improve its efficacy. Methods: One hundred and twenty patients with unresectable advanced esophageal cancer were randomly divided into chemotherapy plus radiotherapy group and radiotherapy alone group, 60 cases each. The two groups of irradiation methods are the same DT50-70GY/5-7 weeks. Chemotherapy uses the FD regimen. Chemotherapy is performed once before and after radiotherapy. Results: The 1-, 2-, and 3-year survival rates were 70.0%, 53.3%, and 31.7% in the chemotherapy plus radiotherapy group. The radiotherapy alone group was 46.7%, 36.7%, and 20.0%. There was a significant difference in the 1-, 2-, and 3-year survival rates between the two groups (P<0.05). Conclusion: The median survival period was significantly higher in the chemotherapy plus radiotherapy group than in the radiotherapy group.