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目的:探讨颅内生殖细胞瘤放射治疗的方法和预后。方法:分析报道14例颅内生殖细胞瘤临床表现、治疗方法和预后。结果:13例完成放疗,全中枢放疗3例。复发1例,为多发病灶者;全脑放疗4例,1例脊髓转移;局部野放疗+化疗1例,无复发;单纯局部野放疗5例,3例复发。1例放疗25Gy无效行手术,术后病理为畸胎瘤。5年和10年生存率分别为72.7％和62.5％。结论:放射治疗是其主要治疗方法,术前应争取病理诊断。全脑+局部放疗是必要的治疗措施,脊髓预防照射可因病情需要选择采取。
Objective: To investigate the method and prognosis of intracranial germinoma radiotherapy. Methods: Analysis of 14 cases of intracranial germinoma clinical presentation, treatment and prognosis. Results: Thirteen patients underwent radiotherapy and 3 patients received total central radiotherapy. Recurrence occurred in 1 patient with multiple lesions. Whole-brain radiotherapy was performed in 4 patients and spinal cord in 1 patient. Local field radiotherapy + chemotherapy was performed in 1 patient. No recurrence was found. Five patients were treated with local field radiotherapy and 3 patients relapsed. One case of radiotherapy 25Gy ineffective surgery, postoperative pathology teratoma. The 5-year and 10-year survival rates were 72.7% and 62.5% respectively. Conclusion: Radiation therapy is the main method of treatment, preoperative pathological diagnosis should be sought. Whole brain + local radiotherapy is a necessary treatment, spinal cord injury may need to choose because of the disease to take.