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目的了解汝城县开展多次麻疹疫苗强化接种后1~15周岁健康儿童的抗体水平,为继续制定免疫规划提供科学依据。方法采集全县1~15周岁少年儿童血液,利用酶联免疫间接法(ELISA)定性检测血清中的麻疹病毒IgG抗体。结果共检测43 982份血清,其中阳性41 778份,阴性2 204份,总体阳性率为94.99%。不同乡镇间以县城周边的麻疹抗体阳性率高,而边远乡镇麻疹阳性率相对较低。10~15岁年龄组麻疹抗体阳性率为94.33%,明显低于1~3岁年龄组麻疹抗体阳性率97.12%,差异有统计学意义(χ2=57.65,P<0.05),全目标年龄阶段男女之间麻疹抗体阳性率差异无统计学意义(χ2=2.36,P>0.05)。结论强化免疫效果好,仍需加强对10~15岁大年龄组少年儿童麻疹疫苗的复种。
Objective To understand the antibody levels of healthy children aged from 1 to 15 years after the repeated immunization with measles vaccine in Rucheng County and to provide a scientific basis for further development of immunization programs. Methods The blood of children aged 1-15 years old was collected and the serum IgG was detected by enzyme-linked immunosorbent assay (ELISA). Results A total of 43 982 sera were detected, of which 41 778 were positive and 2 204 were negative. The overall positive rate was 94.99%. Measles antibody positive rates around the county towns are high among different townships while the positive rate of measles in remote townships is relatively low. The positive rate of measles antibody in the age group of 10-15 years old was 94.33%, which was significantly lower than that of the measles antibody in the age group of 1 ~ 3 years (97.12%), the difference was statistically significant (χ2 = 57.65, P <0.05) Measles antibody positive rate was no significant difference (χ2 = 2.36, P> 0.05). Conclusion The effect of intensive immunization is still good, and it is still necessary to intensify the multi-plantation of measles vaccine for children and adolescents aged 10-15 years.