论文部分内容阅读
利用SP免疫组织化学技术检测 5 5例肝细胞癌 (HCC)及其癌旁组织中p Stat3(Tyr70 5 ) ,c fos和c jun蛋白的表达。结果显示 :HCC中p Stat3,c fos和c jun蛋白阳性率和阳性强度均高于癌旁组织 (P <0 .0 1) ,且p Stat3与c fos和c jun蛋白表达强度均呈明显正相关 ,而在癌旁组织中p Stat3仅与c jun蛋白表达相关 ,提示Stat3蛋白的磷酸化可能是HCC发生的早期事件 ,并通过激活c jun和c fos基因使肝细胞恶性转化 ;癌旁肝组织中 ,p Stat3,c jun或c fos呈阳性表达的肝细胞可能是一种具有恶性潜能的癌前细胞群。
SP immunohistochemistry was used to detect the expression of p Stat3 (Tyr70 5 ), c fos and c jun proteins in 55 cases of hepatocellular carcinoma (HCC) and its adjacent tissues. The results showed that the positive rate and positive intensity of p Stat3, c fos and c jun proteins in HCC were higher than those in adjacent tissues (P < 0.01), and the expression intensity of p Stat3 and c fos and c jun proteins were both positive and positive. In contrast, p Stat3 is only associated with c jun protein expression in paracancerous tissues, suggesting that Stat3 phosphorylation may be an early event of HCC and malignant transformation of hepatocytes by activating c jun and c fos genes; paracancerous liver In tissues, hepatocytes with positive expression of p Stat3, c jun or c fos may be a premalignant cell population with malignant potential.