目的:分析奥美拉唑治疗胃溃疡合并出血的临床疗效。方法:选取我院2012年1月至2014年1月收治的56例胃溃疡合并出血患者为研究对象,随机将其分为两组,对照组患者采取常规治疗,观察组患者在对照组基础上加以奥美拉唑治疗,对两组治疗效果及复发情况进行比较。结果:观察组患者治疗显效22例,好转5例,总有效率96.43%,Hp阴转率82.14%,胃出血复发率7.14%;对照组患者治疗显效15例,好转8例,总有效率82.14%,Hp阴转率53.57%,胃出血复发率32.14%。观察组治疗总有效率、Hp阴转率及胃出血复发率明显优于对照组,差异有统计学意义,P<0.05。结论:常规治疗基础上应用奥美拉唑能有效修复溃疡面,清除Hp,改善出血症状,且复发率较低,值得在胃溃疡合并出血治疗中进一步应用。 Objective: To analyze the clinical efficacy of omeprazole in the treatment of gastric ulcer combined with bleeding. Methods: Fifty-six patients with gastric ulcer combined with hemorrhage admitted to our hospital from January 2012 to January 2014 were selected and randomly divided into two groups. The patients in the control group were treated routinely. The patients in the observation group were divided into two groups based on the control group To omeprazole treatment, the treatment effect and recurrence of the two groups were compared. Results: In the observation group, 22 cases were cured and 5 cases improved. The total effective rate was 96.43%, the Hp negative conversion rate was 82.14%, and the recurrence rate of gastric bleeding was 7.14%. In the control group, 15 cases were cured and 8 cases improved. The total effective rate was 82.14 %, Hp negative conversion rate of 53.57%, gastric bleeding recurrence rate of 32.14%. Observation group, the total effective rate of treatment, Hp negative conversion rate and recurrence rate of gastric bleeding was significantly better than the control group, the difference was statistically significant, P <0.05. CONCLUSION: Omeprazole can effectively repair ulcer surface, clear Hp, improve bleeding symptoms and have a low recurrence rate based on routine treatment. It is worth further application in the treatment of gastric ulcer combined with hemorrhage.