论文部分内容阅读
目的:了解我院药品不良反应(ADR)发生的特点及一般规律。方法:对我院2010年1月-2012年4月上报的125份ADR报告进行回顾性分类统计、分析。结果:静脉给药途径引发的ADR最多,有106例(占84.80%);上报ADR报告的科室分布存在较大差异,报告最多的是大内科系统,其次是儿科门诊;大部分ADR报告是由药师督报和完善的。抗菌药物的ADR发生率最高,有73例(占58.40%),其次为中药制剂、消化系统用药、心血管系统用药等。抗菌药物中头孢菌素类是引发ADR数量最多的一类,喹诺酮类次之,左氧氟沙星是引发ADR数量最多的单一品种(21例,占28.77%)。ADR的临床表现以皮疹、瘙痒等皮肤及其附件损害最常见,有84例(占67.20%)。新的和严重的ADR不多,无后遗症和死亡病例。ADR报告总数偏少,原始报告质量较差,可能有部分ADR病例漏报。结论:应加强ADR的监测、报告工作,提高原始报告质量,采取有效措施杜绝漏报。
Objective: To understand the characteristics and general rules of adverse drug reaction (ADR) in our hospital. Methods: We retrospectively classify and analyze 125 ADR reports reported in our hospital from January 2010 to April 2012. Results: The most ADRs were induced by intravenous route, 106 cases (84.80%). There was a big difference in the distribution of departments reporting ADRs. The most reported cases were major medical systems, followed by pediatric clinics. Most ADRs were reported by Pharmacists supervise and improve. The highest incidence of ADR was antibiotics, with 73 cases (accounting for 58.40%), followed by traditional Chinese medicine preparation, digestive system medication and cardiovascular system medication. Cephalosporins in antibacterials were the most frequently initiated ADRs, followed by quinolones. Levofloxacin was the single species with the highest number of ADRs (21 cases, 28.77%). The clinical manifestations of ADR rash, itching and other skin and its accessories damage the most common, 84 cases (67.20%). No new or serious ADRs, no sequelae, or deaths. The total number of ADR reports is too small, the quality of the original reports is poor, and some cases of ADR may not be reported. Conclusion: The monitoring and reporting of ADR should be strengthened to improve the quality of the original report and take effective measures to eliminate the omission.