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14-3-3蛋白是高度保守的可溶性酸性蛋白家族,近年的研究表明,它们在细胞有丝分裂、生长、分化、增殖和死亡等过程中起重要的调控作用。其中14-3-3σ主要存在于上皮细胞,具有组织特异性,可以与细胞内多种信号蛋白相互作用,促进DNA损伤后的细胞周期G2期阻滞,调控细胞的生长、分化和增殖等多种生物学功能,在肿瘤发生发展过程中表达异常,可能由p53突变或启动子CpG岛超甲基化引起,与人类恶性肿瘤的发生发展及预后密切相关。该文作者仅就14-3-3σ蛋白在人类恶性肿瘤中的研究进展作一综述。
14-3-3 protein is a highly conserved family of soluble acidic proteins. Recent studies have shown that these proteins play an important regulatory role in mitosis, growth, differentiation, proliferation and death of cells. Among them, 14-3-3σ mainly exists in epithelial cells, which is tissue-specific and interacts with many signaling proteins in cells to promote cell cycle G2 arrest after DNA damage and regulate cell growth, differentiation and proliferation. The biological function of the species is abnormal during tumorigenesis, which may be caused by the mutation of p53 or hypermethylation of CpG island of promoter, which is closely related to the occurrence, development and prognosis of human malignant tumors. This article reviews only the progress of 14-3-3σ protein in human malignant tumors.