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将玻璃片/管、锡箔等材料进行组装、通道搭建制备出带有管路图案的容器,再将聚二甲基硅氧烷(PDMS)预聚体浇注到该容器中固化成型,之后通过模具拆卸、切割制备出整体式PDMS微/毫流控芯片.该法可获取各种微通道尺寸保真性好的整体式芯片,其通道截面圆形度与由热压法制备的微流控芯片相比有明显提高.另将获得的PDMS芯片经过30 min紫外改性后,其疏水性得到明显改善,与H2O的接触角由钝角变为了锐角,并在室温下静置能维持1 h左右的改性,完全能够满足液滴成型实验的时间要求.另外将该法制备的PDMS整体式芯片用于单分散液滴、双重液滴制备时,可在较宽的流速范围(4 mL/h~36 mL/h)内得到粒径可控的液滴,并且液滴在芯片通道中不易破乳,表现出良好的稳定性.这对于靶球制备、功能材料合成、活性成分保持等应用有重要意义.
The glass sheet / tube, tin foil and other materials are assembled, the channel is set up to prepare a container with a pipeline pattern, and the polydimethylsiloxane (PDMS) prepolymer is poured into the container to be solidified and shaped, Disassembly and cutting to prepare a monolithic PDMS micro / milli-flow control chip, which can obtain a monolithic chip with good fidelity in microchannel size, the cross-sectional circularity of which is similar to that of the microfluidic chip prepared by the hot pressing method The PDMS chip obtained after 30 min UV modification, the hydrophobicity was significantly improved, and the contact angle with H2O changed from an obtuse angle to an acute angle, and at room temperature can be maintained for about 1 h to change Which can fully meet the time requirement of the droplet forming experiment.In addition, the PDMS monolithic chip prepared by the method can be used for monodisperse droplets and double droplet preparation in a wide range of flow rate (4 mL / h ~ 36 mL / h), and the droplets are not broken easily in the channel of the chip, showing good stability, which is of great significance for the preparation of the target sphere, the synthesis of the functional material and the maintenance of the active ingredient .