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目的:分析小儿药物性肝损伤的临床特点。方法:选择2012年5月-2013年8月在我院诊治的30例小儿药物性肝损伤患者进行回顾性分析,总结临床特点。结果:30例患儿均患有相关病史,病程在3d-60d。肝细胞型是小儿药物性肝损害的主要表现形式,导致出现这种情况的药物有很多种,其中抗生素占第一位。结论:小儿药物性肝损伤首发症状有很多种,很容易造成肝外症状起病,应该与病毒性肝病等相互鉴别。小儿采用抗生素能够引发小儿药物性肝损伤,对小儿进行监测是避免小儿出现药物性肝损伤的主要措施。
Objective: To analyze the clinical features of drug-induced liver injury in children. Methods: A retrospective analysis of 30 pediatric patients with drug-induced liver injury diagnosed and treated in our hospital from May 2012 to August 2013 was conducted to summarize the clinical features. Results: All 30 patients had related medical history, the course of the disease was 3d-60d. Hepatocyte type is a major manifestation of pediatric drug-induced liver damage, leading to a variety of drugs in this situation, of which antibiotics account for the first place. Conclusion: There are many kinds of first symptoms of drug-induced liver injury in children, it is easy to cause the onset of extrahepatic symptoms and should be differentiated from other viral liver diseases. Pediatric use of antibiotics can cause pediatric drug-induced liver injury, monitoring of children is to prevent drug-induced liver injury in children’s major measures.