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微小RNA(micro RNA,mi RNA)是近年来子宫内膜异位症研究的新方向。相关mi RNA的研究通过对比异位内膜组织和正常内膜组织mi RNA的表达差异,得到一些可能参与子宫内膜异位症发生发展的mi RNA。通过对某些特异性表达的mi RNA研究发现,mi RNA可能通过调控靶基因的表达调节异位内膜细胞的侵袭和增殖,比如mi R-let-7b、mi R-199a、mi R-10b通过直接或者间接调节MMPs的表达,从而影响异位内膜细胞的侵袭性;mi R-17-5p和mi R-23a/b可通过调节雌激素的合成促进异位内膜细胞的增殖。此外,mi RNA和子宫内膜异位症相关性不孕的发生也存在密切的关系。
MicroRNA (miRNA) is a new direction of endometriosis in recent years. Related miRNA research by comparing miRNA expression in ectopic endometrium and normal endometrial tissue, to obtain some may participate in the development and progression of endometriosis mi RNA. Through the study of some specific mi RNAs, mi RNAs may regulate the invasion and proliferation of ectopic endometrial cells by regulating the expression of target genes, such as mi R-let-7b, mi R-199a, mi R-10b By directly or indirectly regulating MMPs expression, thereby affecting the invasion of ectopic endometrial cells; mi R-17-5p and mi R-23a / b by regulating the synthesis of estrogen to promote ectopic endometrial cell proliferation. In addition, there is a close relationship between mi RNA and infertility related to endometriosis.