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为探讨病毒性肝炎患者体内细胞免疫功能的变化规律及相互关系。采用APAAP法、斑蝥皮泡法检测T细胞亚群、巨噬细胞吞噬率 (PR)及吞噬指数 (PI) ,并分析其相互关系。结果显示病毒性肝炎组CD3+ 细胞、CD4+ 细胞、CD4+ /CD8+ 比值降低、CD8+ 细胞升高 ,与对照组比较有显著差异 (P <0 0 1) ,各型病毒性肝炎组病人PR与CD4+ /CD8+ 比值正相关 ,其中CAH组相关系数r =0 76 4(P <0 0 5 )。病毒性肝炎患者T细胞及巨噬细胞免疫功能均降低 ,且密切相关。结果有助于了解病毒性肝炎患者免疫功能的整体变化 ,对病毒性肝炎的免疫学诊断及免疫功能调整有一定意义。
To investigate the variation of cellular immune function in patients with viral hepatitis and their relationship. The APAAP method was used to detect T cell subsets, phagocytic rate (PR) and phagocytic index (PI) of macrophages, and the correlation was analyzed. The results showed that the ratio of CD3 + cells, CD4 + cells, CD4 + / CD8 + and CD8 + cells in viral hepatitis group were significantly higher than those in control group (P <0.01) The correlation coefficient was positively correlated with the correlation coefficient (r = 0 764, P <0 05) in the CAH group. Patients with viral hepatitis T cells and macrophages immune function are reduced, and are closely related. The results help to understand the overall changes in immune function in patients with viral hepatitis, immunological diagnosis of viral hepatitis and immune function adjustment of some significance.