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[目的]研究药物洗脱球囊(DEB)用于治疗冠心病患者经皮冠脉介入术(PCI)术后支架内再狭窄(ISR)的临床效果.[方法]回顾性分析 2012 年 1 月至 2017 年 5 月本院收治的因 ISR就诊的 50 例冠心病患者的临床资料,根据支架类型的不同将其分为 DES组和 DEB组.比较两组患者临床基本特征、治疗前后冠脉造影特点,随访治疗后 12 个月内患者发生终点事件的情况.[结果]治疗 6 个月后冠脉造影结果显示,DEB组再狭窄发生率显著低于DES组,差异具有统计学意义(P ＜0.05);两组 TIMI血流Ⅰ级、Ⅱ级、Ⅲ级,血管狭窄程度,支架内及节段内最小管腔直径、晚期管腔丢失比较,差异均无统计学意义(P ＞0.05).DES组支架内二次狭窄发生率为 24.00%(6/25)显著高于 DEB组的 4.00%(1/25),差异具有统计学意义(χ2＝4.153, P ＝0.042＜0.05).应用 Kaplan-Meier生存分析发现,两组患者术后 12 个月内无 MACE生存率比较,差异无统计学意义(χ2＝0.467,P ＝0.494＞0.05).[结论]DEB治疗 ISR的临床效果与 DES相当,且未造成如动脉撕裂夹层等严重并发症,安全性较高.“,”[Objective]To study the clinical effect of drug-eluting balloon (DEB)in the treatment of ISR after percutaneous coronary intervention (PCI)in patients with coronary heart disease.[Methods]The clinical data of 50 pa-tients with coronary heart disease treated by ISR from January 2012 to May 2017 were analyzed retrospectively.Ac-cording to the type of stent,it was divided into DES group and DEB group.The clinical features,coronary angiogra-phy features,and terminal events within 12 months after treatment were compared between the two groups.[Results]After 6 months of treatment,coronary angiography showed that the incidence of restenosis in the DEB group was sig-nificantly lower than that in the DES group (P＜0.05).There was no significant difference in TIMI blood flow gradeⅠ,Ⅱ,Ⅲ,stenosis degree,minimum lumen diameter and late lumen loss between the two groups (P ＞0.05).The incidence of secondary stent stenosis in the DES group was 24.00%(6/25),which was significantly higher than that in the DEB group (4.00%,1/25).The difference was statistically significant(χ2＝4.153,P＝0.042＜0.05).Kap-lan-Meier survival analysis showed that there was no significant difference in MACE free survival rate between the two groups within 12 months after operation (χ2＝0.467,P＝0.494＞0.05).[Conclusion]The clinical efficacy of DEB in the treatment of ISR is comparable to that of DES with high safety,and no serious complications such as artery lacer-ation dissection have been caused.