Potato is one of the important food crops with a high yield potential and nutritional value.It has been used extensively for molecular farming to produce vaccines,antibodies and industrial enzymes.It has several desirable attributes as a favorable crop for the production of recombinant proteins.Potato tubers were employed for bulk production of recombinant antibodies.Vaccine production in potato has progressed to human clinical trials.Human milk proteins were successfully expressed in potato tubers.Potato hairy roots offer as another attractive system for the production of useful recombinant proteins both as intra cellular and secreted forms.This review describes the use of potato as a prospective host for plant molecular farming. Potato is one of the important food crops with a high yield potential and nutritional value. It has been used extensively for molecular farming to produce vaccines, antibodies and industrial enzymes. It has several desirable attributes as a favorable crop for the production of recombinant proteins. Potato tubers were employed for bulk production of recombinant antibodies. Vaccine production in potato has progressed to human clinical trials. Human milk proteins were successfully expressed in potato tubers. Potato hairy roots offer as another attractive system for the production of useful recombinant proteins both as intra cellular and secreted forms. This review describes the use of potato as a prospective host for plant molecular farming.