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研究旨在验证胰酶替代疗法加上饮食调整能提高脂肪、蛋白等吸收以减轻或阻止无法切除的胰头癌病人体重下降的设想。 方法:选择胰头区肿瘤所致阻塞性黄疸并已置胆道内支架,ERCP后2周以上的患者。进行各项必要检查包括有关脂肪的吸收、排出试验后,随机分为胰酶替代治疗及安慰剂治疗2组。胰酶组在三餐及用点心时口服2粒(点心时1粒)Panzytrat(每粒含脂肪酶25000,蛋白酶1250及淀粉酶22500PhEur单位的包肠溶衣微
The aim of the study was to verify that trypsin replacement therapy plus dietary adjustment can increase the absorption of fat, protein, etc. to reduce or prevent weight loss in patients with unresectable pancreatic head cancer. METHODS: Patients with obstructive jaundice caused by tumors in the pancreatic head area were selected and had been placed in the biliary stents. Patients were more than 2 weeks after ERCP. All necessary examinations including fat absorption and discharge tests were randomly assigned to pancreatic enzyme replacement therapy and placebo treatment. In the trypsin group, 2 tablets (1 snack) of Panzytrat (each capsule containing 25,000 lipases, 1250 protease, and 22500 PhEur units of enteric coated microcapsules were taken orally during snacks and snacks)