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目的：测定肝靶向抗癌药NGA—DHAQ中DHAQ的含量。方法：通过均匀设计和正交设计得到肝靶向化学偶联物NGA—DHAQ发生水解而游离出DHAQ的最佳条件：0.5mlNGA—DHAQ液透析中，加入430μl水和70μl浓HCl，水浴90℃恒温40分钟。并在此条件下初步考察了DHAQ的稳定性。结果：建立了NGA—DHAQ中DHAQ含量的测定方法。结论：说明此方法可行。
Objective: To determine the content of DHAQ in NGA-DHAQ. METHODS: Optimal conditions for the hydrolysis of the liver-targeted chemical conjugate NGA-DHAQ to free DHAQ were obtained by uniform design and orthogonal design: 430 μl of water and 70 μl of concentrated HCl were added to 0.5 ml of NGA-DHAQ solution, Constant temperature 40 minutes. Under this condition, the stability of DHAQ was investigated. Results: The method of determination of DHAQ in NGA-DHAQ was established. Conclusion: This method is feasible.