莱姆病 (Lymedisease)螺旋体是引起人畜莱姆病的病原体 ,本文从莱姆螺旋体外膜蛋白的组成、生化结构特征、编码基因及其遗传学特性、致病性和免疫性以及外膜蛋白克隆与表达研究等方面归纳总结了近年来的研究成果 ,并简要介绍了这些研究成果在莱姆病原体分类鉴定 ,莱姆病诊断以及莱姆病疫苗研制中的应用。 Lyme disease (Lymedisease) spirochetes are the pathogens that cause Lyme disease in humans and animals. In this paper, the composition, biochemical structure, gene encoding genes and their genetic characteristics, pathogenicity and immunity as well as outer membrane protein cloning And expression studies summarized the research results in recent years, and briefly introduced the research results in the classification of Lyme pathogens, Lyme disease diagnosis and development of Lyme disease vaccine application.