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目的:探讨白藜芦醇对四氯化碳(CCL4)诱导小鼠急性肝损伤保护作用的机制。方法:建立CCL4诱导小鼠急性肝损伤模型,以血清丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)活性;白细胞介素-6(IL-6)含量;肝匀浆丙二醛(MDA)含量及超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-PX)、过氧化氢酶(CAT)活性为检测指标,观察白藜芦醇对实验性肝损伤保护作用的机制。结果:白藜芦醇呈剂量依赖性降低CCL4小鼠血清中ALT、AST活性,降低肝匀浆MDA含量,提高肝匀浆SOD、GSH-PX、CAT活性,降低血清中IL-6水平。结论:白藜芦醇可通过抗氧化作用及抑制IL-6表达而产生对肝脏的保护作用。
Objective: To investigate the protective effect of resveratrol on acute liver injury induced by carbon tetrachloride (CCL4) in mice. Methods: Acute liver injury induced by CCL4 was induced in mice. Serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), interleukin-6 (IL-6) The content of malondialdehyde (MDA) and the activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-PX) and catalase (CAT) Mechanisms of protective effects of experimental liver injury. Results: Resveratrol could decrease the activity of ALT and AST in serum, decrease the content of MDA in liver homogenate, increase the activity of SOD, GSH-PX and CAT and decrease the level of IL-6 in CCL4 mice in a dose-dependent manner. Conclusion: Resveratrol can protect the liver through its antioxidation and inhibition of IL-6 expression.