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目的 研究紫杉醇治疗对阿霉素、氟尿嘧啶在内的多种抗癌药耐药患者的临床疗效。 方法 32例病理证实的乳腺癌患者从前均接受过阿霉素、氟尿嘧啶治疗但无效 ,再给予紫杉醇治疗观察临床疗效。 结果 32例中 ,完全缓解 2例 ,占 6 3 % ,平均缓解期为 6个月。部分缓解 10例 ,占 31 3 % ,平均缓解期 4个月。有效率为37 5 %。 结论 紫杉醇对耐药乳腺癌的疗效较好 ,对于难治性晚期乳腺癌 ,紫杉醇是首选药物
Objective To study the clinical efficacy of paclitaxel in the treatment of multidrug resistant patients including adriamycin and fluorouracil. Methods 32 cases of pathologically confirmed breast cancer patients were previously treated with doxorubicin and fluorouracil but were ineffective. Paclitaxel was then given to observe clinical efficacy. Results Of the 32 patients, 2 patients had complete remission, accounting for 63%, and the average remission period was 6 months. Partial remission in 10 cases, accounting for 31%, with an average remission period of 4 months. The effective rate is 37 5 %. Conclusion Paclitaxel has a good effect on resistant breast cancer. Paclitaxel is the drug of choice for refractory advanced breast cancer.