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β阻滞剂对于动物试验和病人的心肌缺血都显示了有益的作用。当冠状动脉梗阻而迅速发生心肌梗塞后,β阻滞剂能抑制实验性心肌梗塞面积的扩大。 临床中,急性心肌梗塞患者接受β阻滞剂治疗,可以减少心排血量、降低动脉压、减慢心率、减少心肌耗氧量,从而减轻了心肌局部缺血的严重程度。对于透壁性或非透壁性急性心肌梗塞,β阻滞剂可减轻病人胸痛、减轻S—T段的抬高、改善室壁活动、增加存活率。GoLd氏等发现除临床和心电图改善外,冠状动脉造影证实,可增加梗塞区的侧枝循
Beta blockers have shown beneficial effects both in animal experiments and in patients with myocardial ischemia. Beta blockers inhibit the expansion of experimental myocardial infarction when coronary artery obstruction quickly develops myocardial infarction. Clinical, patients with acute myocardial infarction received beta blocker therapy, can reduce cardiac output, reduce arterial pressure, heart rate, reduce myocardial oxygen consumption, thereby reducing the severity of myocardial ischemia. For transmural or non-transmural acute myocardial infarction, β blockers can reduce chest pain in patients, reduce the elevation of S-T segment, improve wall activity and increase survival rate. GoLd’s found that in addition to clinical and ECG improvement, coronary angiography confirmed that can increase the collateral circulation infarction