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水杨酸(通常以水杨酸钠或阿司匹林投药)是临床最常用药物之一。目前不仅在止痛、抗炎、退热和治疗痛风等方面有重要地位,由于有抗凝作用,在预防静脉血栓、冠脉血栓和肺栓塞等方面也可能有一定功效。 水杨酸用作抗炎和镇痛药治疗风湿热和类风湿关节炎时,血浆最适治疗浓度范围很窄,约15—30mg/100ml。而血浆浓度在25—35mg/100ml时即可出现中毒症状。在临床中毒病例中,特别是婴儿和儿童水杨酸急性中毒,几乎都是由于给药方案不当造成。
Salicylic acid (usually administered as sodium salicylate or aspirin) is one of the most commonly used drugs in the clinic. At present, not only analgesic, anti-inflammatory, antipyretic and the treatment of gout and so has an important position, due to anticoagulant effects, in the prevention of venous thrombosis, coronary thrombosis and pulmonary embolism may also have some effect. Salicylic acid used as anti-inflammatory and analgesic drugs for the treatment of rheumatic fever and rheumatoid arthritis, the optimum plasma concentration range is very narrow, about 15-30mg / 100ml. The plasma concentration of 25-35mg / 100ml poisoning symptoms can occur. In clinical poisoning cases, especially acute poisoning of salicylic acid in infants and children, almost all due to improper dosing regimen.