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目的探讨氟西汀 (商品名百忧解 )对非溃疡性消化不良 (NUD)患者的症状及胃排空功能的影响。方法将 44例胃排空延缓的NUD患者随机分为两组 ,一组服用氟西汀 ,另一组服用莫沙必利进行治疗 ,疗程 4周。观察患者治疗前后的胃排空功能变化 ,并对其治疗前后的症状分别进行积分。结果两组患者治疗后症状均有显著改善 ,两组间疗效比较无显著性差异 (P>0 .0 5 )。治疗后 ,两组患者胃排空均明显加速 ,以莫沙必利组更为显著。结论氟西汀既能作用于中枢神经系统 ,增强患者对躯体不适的耐受性 ,又能间接加速胃排空而发挥对 NUD的治疗作用
Objective To investigate the effect of fluoxetine (a product of Prozac) on the symptoms and gastric emptying in patients with non-ulcer dyspepsia (NUD). Methods Forty-four patients with gastric emptying delayed NUD were randomly divided into two groups: one was fluoxetine, and the other was treated with mosapride for 4 weeks. The changes of gastric emptying function before and after treatment were observed, and the symptoms before and after treatment were separately integrated. Results After treatment, the symptoms of both groups were significantly improved. There was no significant difference between the two groups (P> 0.05). After treatment, gastric emptying was significantly accelerated in both groups, more significantly in the mosapride group. Conclusion Fluoxetine can not only act on the central nervous system, enhance patient tolerance to physical discomfort, but also indirectly accelerate gastric emptying and exert the therapeutic effect on NUD