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目的探讨砷对机体ＮＯ的影响及ＮＯ在砷中毒发病中的作用。方法采用动物实验和人群调查方法。结果慢性染砷实验中，小鼠血清、肾脏ＮＯ２－／ＮＯ３－含量中、高剂量组显著降低，肝脏、心脏ＮＯ２－／ＮＯ３－含量各剂量组显著降低，且呈剂量—效应关系。全血ＧＳＨ含量低剂量组显著升高，中、高剂量组显著降低，肝脏、心脏ＧＳＨ含量各剂量组均显著下降，肾脏ＧＳＨ含量中、高剂量组显著降低。红细胞、心脏ＳＯＤ活性中、高剂量组显著下降，肝脏ＳＯＤ活性低剂量组显著升高，中、高剂量组显著下降，肾脏各剂量组未见显著差异。人群调查，砷病区病人血中ＮＯ２－／ＮＯ３－、ＧＳＨ含量显著低于非病区健康人，且二者呈正相关，红细胞ＳＯＤ活性未见显著差异。结论砷可导致ＮＯ含量的下降。砷可导致ＧＳＨ含量和ＳＯＤ活性的变化，进而影响ＮＯ合成和代谢
Objective To investigate the effect of arsenic on NO and the role of NO in the pathogenesis of arsenism. Methods Animal experiments and population survey methods. Results In chronic arsenic exposure experiment, the levels of NO2- / NO3- in serum and kidneys of mice were significantly decreased, and the levels of NO2- / NO3- in liver and heart were significantly decreased in dose-dependent manner. GSH content of whole blood in low dose group was significantly increased, middle and high dose group was significantly reduced, liver, heart GSH content of each dose group were significantly decreased, the renal GSH content of middle and high dose group was significantly lower. The activities of SOD and SOD in erythrocytes and heart decreased significantly in low-dose group and low-dose group, while those in middle-dose and high-dose group decreased significantly. There was no significant difference in each dose group. Population survey, arsenic ward patients blood NO2- / NO3-, GSH content was significantly lower than non-ward healthy people, and the two was positively correlated, no significant difference in erythrocyte SOD activity. Conclusion Arsenic can lead to the decrease of NO content. Arsenic can cause changes in GSH content and SOD activity, thereby affecting NO synthesis and metabolism