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目的:研究急性心肌梗死经皮冠状动脉介入治疗患者甲状腺功能与血小板检测结果之间的关系。方法:选取2014年12月至2016年2月入住西安交通大学第一附属医院,且诊断为急性心肌梗死(AMI)的患者为AMI组,对照组为不稳定型心绞痛(UA)患者。共纳入患者122例,其中男性88人,女性34人。AMI组77人,UA组患者45人。比较两组临床基线资料。血生化指标包括:HbA1c、血糖、LDL-C、HDL-C、TG、LPA、CREA、UA、hsCRP、BNP、CKMB、cTNI、D-Dimer。心功能检测指标为EF(%)。甲状腺功能指标:TT3,TT4,FT3,FT4,TSH。依据患者血清FT3水平四分位数二次分组,比较组间血小板相关检测结果:PLT、MPV、PDW、P-LCR,hsCRP、D-Dimer的差异情况。分析FT3与MPV的相关性。结果:UA组和AMI组之间,hsCRP、BNP、CKMB、CTNI、D-Dimer差异具有明显的统计学意义(P<0.01)。FT3、FT4差异具有明显的统计学意义(P<0.01)。而TSH、TT3、TT4的没有明显的差异(P>0.05)。在以FT3四分位数进行分组中,越低的FT3,会有越高的MPV,hsCRP和D-Dimer。结论:AMI组伴有明显的FT3,TT3的降低,且AMI组FT3与TT3有良好的相关性,越低的FT3会有越高的MPV,hsCRP和D-Dimer。急性心肌梗死患者较低的FT3可以预测患者的临床风险的增加。
Objective: To study the relationship between thyroid function and platelet count in patients undergoing percutaneous coronary intervention for acute myocardial infarction. Methods: The patients admitted to the First Affiliated Hospital of Xi’an Jiaotong University from December 2014 to February 2016 were selected as the AMI group and the control group as the patients with unstable angina pectoris (UA). A total of 122 patients were enrolled, including 88 males and 34 females. 77 in the AMI group and 45 in the UA group. Two sets of clinical baseline data were compared. Blood biochemical indicators include: HbA1c, blood glucose, LDL-C, HDL-C, TG, LPA, CREA, UA, hsCRP, BNP, CKMB, cTNI, D-Dimer. Heart function test indicators for EF (%). Thyroid function indicators: TT3, TT4, FT3, FT4, TSH. According to the quartiles of patients’ FT3 levels, the results of platelet-related test were compared between groups: the differences of PLT, MPV, PDW, P-LCR, hsCRP and D-Dimer. Analyze the correlation between FT3 and MPV. Results: The differences of hsCRP, BNP, CKMB, CTNI and D-Dimer between UA group and AMI group were statistically significant (P <0.01). FT3, FT4 difference has obvious statistical significance (P <0.01). There was no significant difference between TSH, TT3 and TT4 (P> 0.05). In grouping with FT3 quartiles, the lower the FT3, the higher MPV, hsCRP, and D-Dimer will be. CONCLUSIONS: There is a significant decrease of FT3 and TT3 in AMI group, and there is a good correlation between FT3 and TT3 in AMI group. The lower FT3 is, the higher of MPV, hsCRP and D-Dimer. Lower FT3 in patients with AMI predicts an increase in the patient’s clinical risk.