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目的母婴乙肝病毒垂直传播已成为我国乙肝病毒感染的主要途径,本研究分析乙肝病毒感染的孕妇进行羊膜腔穿刺是否增加母婴垂直传播的风险。方法搜索1990年1月1日~2016年3月15日之间在Pubmed、Embase、谷歌学术和万方数据库等数据库中所有关于乙肝孕妇行羊膜腔穿刺对母婴垂直传播影响的相关英文或中文文章,根据纳入剔除标准对文章进行筛选,然后对文章治疗评分,最后有4篇文章纳入,共有3997孕妇,其中实验组167名、对照组3830名,使用Review Manager Version 5.0进行数据分析。结果荟萃分析结果显示,进行羊膜腔穿刺术与不行羊膜腔穿刺术两组婴儿HBsAg阳性率无明显差异(R~2=1.37,95%CI:0.70~2.69,P=0.36)。当孕妇是HBV-DNA≥10~7 copies/mL、HBeAg阳性时,进行羊膜腔穿刺术后胎儿宫内感染风险增加(R~2=9.54,95%CI:3.52~25.85,P<0.0004;R~2=3.41,95%CI:1.05~11.13,P=0.04)。结论孕妇HBV-DNA≥107 copy/mL和(或)HBeAg阳性时将增加母婴垂直传播的风险。
The purpose of the vertical transmission of mother to child hepatitis B virus has become the main way of hepatitis B virus infection in our country, this study analysis of hepatitis B virus infection in pregnant women for amniocentesis whether to increase the risk of vertical transmission of mother to child. METHODS: We searched all databases of Pubmed, Embase, Google Scholar and Wanfang Database for the correlation between the effect of amniocentesis on the vertical transmission of mother to child in pregnant women with hepatitis B from January 1, 1990 to March 15, Articles were screened based on inclusion criteria and then scored for article therapy. Finally, 4 articles were included, with a total of 3997 pregnant women, including 167 in the experimental group and 3830 in the control group. Data were analyzed using Review Manager Version 5.0. Results The meta-analysis showed no significant difference in HBsAg positive rate between two groups (R ~ 2 = 1.37, 95% CI: 0.70 ~ 2.69, P = 0.36). When pregnant women were HBV-DNA ≥10 ~ 7 copies / mL, HBeAg-positive, the risk of intrauterine infection increased after amniocentesis (R ~ 2 = 9.54,95% CI: 3.52 ~ 25.85, P <0.0004; ~ 2 = 3.41, 95% CI: 1.05 ~ 11.13, P = 0.04). Conclusion Pregnant women with HBV-DNA ≥ 107 copies / mL and / or HBeAg-positive will increase the risk of vertical transmission of mother and baby.