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目的探讨血清胱抑素C(CysC)、β2-微球蛋白(β2-MG)与ABO溶血病(ABOHDN)致肾损伤的关系。方法对40例ABO溶血病和20例正常新生儿的血清胱抑素C、β2-微球蛋白、尿素氮(BUN)、肌酐(Ccr)进行测定。结果由表中可见ABO溶血病组血清胱抑素C、β2-微球蛋白及总胆红素明显高于对照组,而血尿氮及肌酐两组相比差异无统计学意义。结论血清胱抑素C、β2-微球蛋白对ABO溶血病肾损害的早期诊断、治疗及防止其进一步发展有重要临床意义。
Objective To investigate the relationship between cystatin C (CysC), β2-microglobulin (β2-MG) and renal injury induced by ABO hemolytic disease (ABOHDN). Methods Serum levels of cystatin C, β2-microglobulin, blood urea nitrogen (BUN) and creatinine (Ccr) were determined in 40 patients with ABO hemolytic disease and 20 normal newborn infants. Results It can be seen from the table that the levels of cystatin C, β2-microglobulin and total bilirubin in ABO hemolytic disease group were significantly higher than those in control group, but there was no significant difference between the two groups in blood urea nitrogen and creatinine. Conclusion Serum cystatin C and β2-microglobulin have important clinical significance in early diagnosis, treatment and prevention of further development of ABO hemolytic disease and renal damage.