肝脏是晚期结直肠癌患者最常见的转移部位，一旦出现肝转移，患者预后极差。早期诊断结肠癌肝转移(CRLM)对于改善患者预后有重要意义。手术切除原发病灶及转移病灶是唯一可能治愈的方法，转化治疗、介入治疗以及多学科团队治疗也为CRLM治疗提供了更多思路。长链非编码RNA、肿瘤干细胞以及磷脂酰肌醇-3-激酶/蛋白激酶B信号通路揭示了CRLM的机制。本文主要对CRLM诊断和监测、治疗以及主要机制研究的最新进展进行综述。“,”Liver is the most common metastatic organ in patients with advanced colorectal cancer. Once colorectal cancer liver metastasis (CRLM) occurs, the prognosis will be poor. Therefore early detection of CRLM has a great clinical significance for improving the prognosis of CRLM patients. Surgical resection of primary and metastatic lesion is the only possible curable option for CRLM, translational therapy, interventional therapy and multidisciplinary team also provide more treatment ideas. Long non-coding RNA, cancer stem cells and phosphatidylinositide-3-kinases/protein kinase B signaling pathway reveal the main mechanism of CRLM from different aspects. This article reviews the recent advances in the early diagnosis, treatments and main mechanisms of CRLM.