目的探索睡眠呼吸暂停综合征患者nCPAP治疗压力和疗效的相关影响因素。方法先将OSAS患者根据AHI分度进行治疗前后分析,再将患者根据肥胖程度进行治疗前后分析。结果患者nCPAP治疗压力与AHI、BMI正相关,相关系数顺次分别为0.47、0.38。重度患者BMI、颈围、治疗压力高于中度患者(P<0.01)。治疗前轻度肥胖组AHI、压力高于非肥胖组(P<0.01),中度肥胖组AHI、压力高于轻度肥胖组(P<0.01),中度肥胖组minSaO2低于轻度肥胖组(P<0.01),轻度肥胖组minSaO2低于非肥胖组(P<0.01)。治疗后各组压力无明显改变(P>0.05)。治疗后非肥胖组minSaO2高于轻度肥胖组及中度肥胖组(P<0.01)。各组治疗前后压力差异无统计学意义。结论患者不仅AHI,而且BMI、颈围也对nCPAP治疗压力和疗效存在影响。故在nCPAP呼吸机压力滴定和评估疗效时,要综合考虑以上多种因素的影响,并在拟定其他辅助治疗方案时减肥应放在首要位置。 Objective To explore the influencing factors of nCPAP treatment pressure and efficacy in patients with sleep apnea syndrome. Methods The patients with OSAS were analyzed before and after treatment according to AHI index, and then the patients were analyzed before and after treatment according to the degree of obesity. Results The nCPAP treatment pressure was positively correlated with AHI and BMI, and the correlation coefficients were 0.47 and 0.38 respectively. Severe patients BMI, neck circumference, treatment pressure was higher than moderate (P <0.01). Before treatment, the AHI in mild obesity group was higher than that in non-obese group (P <0.01), moderate obesity group was higher than mild obesity group (P <0.01), moderate obesity group was lower than mild obesity group (P <0.01). The minSaO2 in mild obesity group was lower than that in non-obese group (P <0.01). After treatment, the pressure of each group had no significant change (P> 0.05). After treatment, the non-obese group minSaO2 higher than the mild obesity group and moderate obesity group (P <0.01). There was no significant difference in pressure between before and after treatment in each group. Conclusions Patients not only AHI, but also BMI and neck circumference also have influence on nCPAP treatment pressure and efficacy. Therefore, nCPAP ventilator pressure titration and assessment of efficacy, we must take into account the impact of a variety of factors, and in the development of other adjuvant therapy to lose weight should be placed in the first place.