BRCA1(breast cancer susceptibility gene 1)作为一个肿瘤抑制基因,与遗传性卵巢癌(hereditary ovarian cancer syndrome,HOCS)的发生高度相关。该基因通过不同途径对细胞进行调节与监控。BRCA基因突变为生殖细胞突变,按照常染色体显性遗传的方式在家族中传递,从而导致了遗传性卵巢癌的发生。对BRCA1基因进行检测,并从某些环节给予干预,可能为遗传性卵巢癌的预防及治疗提供新思路。 As a tumor suppressor gene, breast cancer susceptibility gene 1 (BRCA1) is highly correlated with the occurrence of hereditary ovarian cancer syndrome (HOCS). The gene regulates and monitors cells through different pathways. BRCA gene mutations into germ cell mutations, according to autosomal dominant manner in the family transmission, which led to the occurrence of hereditary ovarian cancer. The detection of BRCA1 gene and intervention from some aspects may provide new ideas for the prevention and treatment of hereditary ovarian cancer.