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作者曾将 1型副流感病毒(PIV1)血凝素-神经氨酸酶和融合蛋白基因替代PIV3反基因组cDNA中的相应基因,制备重组嵌合 PIV3-PIV1病毒,称为 rPIV3-1。 rPIV3-1在细胞中和仓鼠体内的生长特性类似于野型病毒,并具有PIV1的主要保护性抗
The authors prepared a recombinant chimeric PIV3-PIV1 virus called rPIV3-1 by replacing the corresponding gene in the PIV3 antigenomic cDNA with the hemagglutinin-neuraminidase and fusion protein type 1 parainfluenza virus (PIV1). The growth characteristics of rPIV3-1 in cells and in hamsters are similar to wild-type virus and have the major protective anti-PIV1