目的探讨HMGA2在乳腺组织中的表达及其临床意义。方法应用RT-PCR一步法检测92例女性乳腺疾病中HMGA2基因的表达情况。结果 HMGA2在乳腺良性疾病无表达,而在乳腺癌中高度表达。结论 HM-GA2是乳腺癌的一种特异肿瘤标记物,基因表达与乳腺癌的分期和肿瘤大小密切相关,其高度表达反映乳腺癌的恶性进程。 Objective To investigate the expression of HMGA2 in breast tissue and its clinical significance. Methods RT-PCR one-step method was used to detect the expression of HMGA2 gene in 92 cases of female breast diseases. Results HMGA2 was not expressed in benign breast disease, but highly expressed in breast cancer. Conclusion HM-GA2 is a specific tumor marker of breast cancer. The gene expression is closely related to the stage and tumor size of breast cancer. The high expression of HM-GA2 reflects the malignant progression of breast cancer.