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目的探讨兔眼小梁切除术中联合晶状体前囊膜植入的疗效及机制。设计随机对照实验性研究。研究对象新西兰白兔36只。方法36只兔随机分成3组,分别行小梁切除联合兔晶状体前囊膜植入、小梁切除联合人晶状体前囊膜植入以及单纯小梁切除术对照组。随访时间12周。主要指标眼压、滤过泡、并发症。结果小梁切除联合兔晶状体前囊膜植入组及人晶状体前囊膜植入组术后12周眼压分别为(18．66±2．61)mmHg、(18．91±2．04)mmHg,仍明显低于术前(22．58±0．51)mmHg、(22．21±0．69)mmHg(P均＜0．05)。两实验组功能性滤过泡平均存留时间高于对照组,分别为(5．12±0．43)周、(5．05±0．59)周,(2．74±0．32)周(P＜0．05)。光镜观察实验组术后12周滤过道开放,对照组滤过道基本闭合;电镜观察晶状体前囊膜未见T及B淋巴细胞浸润。结论小梁切除术联合晶状体前囊膜植入可推迟滤过道瘢痕形成,为临床应用提供了理论基础及实验依据。(眼科,2007,16: 52-55)
Objective To investigate the efficacy and mechanism of combined anterior capsule encapsulation in rabbit trabeculectomy. Design Randomized controlled experimental study. Thirty-six New Zealand white rabbits Methods Thirty - six rabbits were randomly divided into three groups. They were treated by trabeculectomy combined with anterior capsule implantation of rabbit lens, trabeculectomy combined with anterior lens capsule implantation and trabeculectomy group. Follow-up time of 12 weeks. The main indicators of intraocular pressure, filtration bleb, complications. Results The intraocular pressure (IOP) at 12 weeks after trabeculectomy combined with anterior lens capsule implantation in rabbits and anterior capsule implantation group were (18.66 ± 2.61) mmHg and (18.91 ± 2.04) mmHg, still significantly lower than the preoperative (22.58 ± 0.51) mmHg, (22.21 ± 0.69) mmHg (P all <0.05). The average retention time of functional bleb in the two experimental groups was (5.12 ± 0.43) weeks, (5.05 ± 0.59) weeks and (2.74 ± 0.32) weeks respectively (P <0.05). Light microscope observation of the experimental group 12 weeks after the opening of the filtration passage, the control group was basically closed filtration passage; electron microscopy showed no anterior capsule T and B lymphocyte infiltration. Conclusion Trabeculectomy combined with anterior capsule encapsulation can delay the formation of scar in filtration tract, which provides a theoretical basis and experimental evidence for clinical application. (Ophthalmology, 2007, 16: 52-55)