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目的探讨家族遗传因素对过敏性紫癜(HSP)发病的影响。方法回顾安徽医科大学第一附属医院儿科2004年1月-2010年12月所有住院HSP患儿的住院病历,对其中5个家族11个同胞亲属先后患HSP的临床资料进行分析。结果 (1)2004年1月-2010年12月收住院HSP患儿1 520例,其中有5个家族11个同胞亲属先后患HSP;(2)5个家族中3个家族为同胞兄弟姐妹先后患病,另2个家族5个患儿为表兄弟;(3)同胞亲属先后发病的间隔时间最短1周,最长3 a;(4)11个先后患病的同胞亲属经治疗病情均得到有效控制;随访1～6 a,其中1例症状复发3次,2例症状分别复发1次,经再次治疗病情缓解,现全部病例病情均处于完全缓解中。结论儿童HSP有家族集聚发病倾向,遗传因素可能在HSP发病中起重要作用。
Objective To investigate the influence of familial hereditary factors on the pathogenesis of Henoch-Schonlein purpura (HSP). Methods The hospital records of all hospitalized HSP children from January 2004 to December 2010 in Pediatrics of the First Affiliated Hospital of Anhui Medical University were retrospectively analyzed, and the clinical data of HSPs in which 11 relatives of 5 families were followed were analyzed. Results (1) From January 2004 to December 2010, there were 1 520 cases of HSP inpatients admitted to hospital, of which 5 relatives of 5 families and 11 relatives had HSP; (2) 3 families in 5 families were siblings (3) the relatives of their relatives had the shortest interval of 1 week, the longest 3 a; (4) the 11 relatives of sick relatives have been treated after the illness have been Effective control; follow-up 1 ~ 6 a, of which 1 case of recurrent symptoms 3 times, 2 cases of recurrent symptoms were again treated by remission of illness, all cases are in complete remission of the disease. Conclusion There is a tendency of familial aggregation in children with HSP, and genetic factors may play an important role in the pathogenesis of HSP.