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目的探讨联用甘精胰岛素与二甲双胍治疗2型糖尿病的临床疗效。方法按就诊顺序编号将我院2012年1月~2014年1月收治的112例2型糖尿病患者分为对照组和观察组,每组56例。两组患者均采用二甲双胍治疗,其中对照组联用优必林N,观察组联用甘精胰岛素。经治疗12w后比较两组患者的血糖控制效果。结果与治疗前相比,两组患者的空腹血糖(FPG)、餐后2h血糖(2hPG)及糖化血红蛋白(HbA1c)水平等指标均明显降低,其中观察组的血糖控制效果要好于对照组,差异均具有统计学意义(P<0.05);观察组的血糖达标时间短于对照组,胰岛素日用量少于对照组,低血糖发生率也低于对照组,上述指标组间比较差异均具有统计学意义(P<0.05)。结论联用甘精胰岛素与二甲双胍治疗2型糖尿病不仅可获得良好的血糖控制效果,而且综合疗效突出,同时低血糖发生率也较低,治疗的安全性较高,值得临床借鉴和推广。
Objective To investigate the clinical efficacy of insulin glargine and metformin in the treatment of type 2 diabetes mellitus. Methods According to the order of treatment, 112 patients with type 2 diabetes mellitus admitted to our hospital from January 2012 to January 2014 were divided into control group and observation group, 56 cases in each group. Two groups of patients were treated with metformin, the control group combined with Ubbelimin N, observation group combined with insulin glargine. After 12 weeks of treatment, the blood sugar control effect was compared between the two groups. Results Compared with those before treatment, the levels of fasting blood glucose (FPG), postprandial 2h blood glucose (2hPG) and HbA1c in both groups were significantly lower than those in the control group, and the control group had better glycemic control than the control group (P <0.05). The observation group’s blood glucose compliance time was shorter than the control group, insulin daily consumption was less than the control group, the incidence of hypoglycemia was also lower than the control group, the above indicators were statistically significant differences between groups Significance (P <0.05). Conclusions The combination of insulin glargine and metformin in type 2 diabetes mellitus can not only achieve a good blood sugar control effect, but also have a good overall effect, low incidence of hypoglycemia and high safety of treatment, which is worthy of clinical reference and promotion.