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疱疹病毒VP16蛋白是疱疹病毒重要的皮层蛋白,参与病毒立即早期基因转录的激活、病毒在宿主细胞内的装配与释放等过程,与许多病毒蛋白和宿主蛋白都存在蛋白相互作用,且部分疱疹病毒VP16具有去泛素活性以及帮助病毒抵御宿主免疫的功能。本文将以疱疹病毒VP16蛋白的结构特点为基础来阐述VP16的功能及其复杂的相互作用,为深入研究疱疹病毒的成熟过程以及VP16涉及的相互作用提供参考。
The herpes virus VP16 protein is an important cortical protein of herpes virus. It is involved in the activation of the immediate early gene transcription of the virus, the process of assembly and release of the virus in the host cell, protein interaction with many viral proteins and host proteins, and the partial herpes virus VP16 has deubiquitinating activity and helps the virus to defend the host immune function. Based on the structural features of VP16 protein of herpesvirus, this paper describes the function and complex interaction of VP16 protein, providing a reference for further study on the maturation of herpesvirus and the interaction of VP16.