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急性高原反应(acute mountain sickness,AMS)指长期生活在低海拔地区的人快速进驻海拔3 000m以上的高原后,机体在短时间内受缺氧、低气压等高原环境因素影响,出现头昏、头痛、恶心、呕吐、睡眠障碍等一系列综合征。低氧诱导因子-1(hypoxic inducible factor,HIF-1)作为一种介导低氧适应性反应的转录因子,低氧时在肝、肾、脑、心等组织细胞中广泛表达,是低氧条件下维持氧稳态的关键性物质,介导低氧反应,是总调节因子。HIF-1由两个亚基构成,一个120kD的α亚基和一个
Acute mountain sickness (AMS) refers to the long-term living in low-altitude areas quickly stationed at an altitude of 3000m above the plateau, the body in a short time by hypoxia, depression and other high altitude environmental factors, dizziness, Headache, nausea, vomiting, sleep disorders and a series of syndromes. Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that mediates hypoxia adaptive response. It is widely expressed in tissues of liver, kidney, brain and heart, Under the conditions of maintaining oxygen homeostasis of key substances, mediated hypoxia, is the total regulator. HIF-1 consists of two subunits, a 120 kD alpha subunit and one