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本文介绍了一种新的左旋多巴制备方法,即以L-酪氨酸为起始原料,经溴代反应制得3-溴-L-酪氨酸,再经无配体参与的铜离子催化羟基化反应制得左旋多巴,总收率约59%。
This article describes a new preparation method of levodopa, that is, L-tyrosine as the starting material, the bromination reaction of 3-bromo-L-tyrosine, followed by ligand-free copper ions Catalytic hydroxylation of levodopa, the total yield of about 59%.