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目的:探讨针刺对2型糖尿病大鼠胰岛素、抵抗素的影响.方法:将造模成功的大鼠按随机化原则分为针刺组、西药组、模型组,同时将普食组大鼠作为正常对照组,每组各8只.针刺组大鼠放入固定器中,取“后三里”(相当于足三里)、“内庭”和“胰俞”穴针刺治疗,西药组用罗格列酮灌胃,模型组用双蒸水灌胃,1次/d,连续4周.实验结束后,动物取材,检测胰岛素、抵抗素.结果:针刺组在血糖、血脂明显降低的同时,血清胰岛素、抵抗素显著降低;西药组抵抗素与模型组相比明显下降,但胰岛素无明显下降.结论:针刺对2型糖尿病大鼠血清胰岛素、抵抗素有明显降低作用,从而有效改善胰岛素抵抗.“,”Objective To explore the effect of acupuncture on insulin and resistin in type 2 diabetes mellitus(DM)rats.Methods Successfully modeled rats were randomly divided into the acupuncture group,the western medicine group,and the model control group,8 cases in each group.Meanwhile,8 rats fed with common food were set up as the normal control group.Rats in the acupuncture group were put in the fixator,and acupuncture was conducted at“Hòsānlǐ”(后三里ST 36),“Nèitíng”(内庭 ST 44)and“Yíshū”(胰俞 Extra).Rosiglitazone was given to rats in the western medicine group by gastrogavage.Double distilled water was given to rats in the model group by gastrogavage.The treatment was conducted once daily in all the 3 groups for 4 successive weeks.After ending the experiments,the blood in rats samples were got.The insulin and resistin were detected.Results The serum levels of insulin and resistin were significantly lowered in the acupuncture group,accompanied with significantly lowered blood glucose and blood lipids.Compared with the model group,the resistin was obviously lowered in the western medicine group,with no significant lowering of insulin.Conclusion Acupuncture showed obvious effects in lowering serum insulin and rsistin in type 2 DM rats,thus effectively improving insulin resistance.